| Fri, Mar 13 | vsDuke Blue DevilsT. Rowe Price ACC Tournament - SemifinalSpectrum Center | L 61–73 | Spectrum Center |
| Thu, Mar 12 | vsNorth Carolina Tar HeelsT. Rowe Price ACC Tournament - QuarterfinalSpectrum Center | W 80–79 | Spectrum Center |
| Wed, Mar 11 | vsWake Forest Demon DeaconsT. Rowe Price ACC Tournament - 2nd RoundSpectrum Center | W 71–62 | Spectrum Center |
| Sat, Mar 7 | vsGeorgia Tech Yellow JacketsWeek 18Littlejohn Coliseum | W 79–76 | Littlejohn Coliseum |
| Tue, Mar 3 | @North Carolina Tar HeelsWeek 18Dean E. Smith Center | L 63–67 | Dean E. Smith Center |
| Sat, Feb 28 | vsLouisville CardinalsWeek 17Littlejohn Coliseum | W 80–75 | Littlejohn Coliseum |
| Sat, Feb 21 | vsFlorida State SeminolesWeek 16Littlejohn Coliseum | L 65–70 | Littlejohn Coliseum |
| Wed, Feb 18 | @Wake Forest Demon DeaconsWeek 16LJVM Coliseum | L 77–85 | LJVM Coliseum |
| Sat, Feb 14 | @Duke Blue DevilsWeek 15Cameron Indoor Stadium | L 54–67 | Cameron Indoor Stadium |
| Wed, Feb 11 | vsVirginia Tech HokiesWeek 15Littlejohn Coliseum | L 66–76 | Littlejohn Coliseum |
| Sat, Feb 7 | @California Golden BearsWeek 14Haas Pavilion | W 77–55 | Haas Pavilion |
| Wed, Feb 4 | @Stanford CardinalWeek 14Maples Pavilion | W 66–64 | Maples Pavilion |
| Sat, Jan 31 | vsPittsburgh PanthersWeek 13Littlejohn Coliseum | W 63–52 | Littlejohn Coliseum |
| Sat, Jan 24 | @Georgia Tech Yellow JacketsWeek 12McCamish Pavilion | W 77–63 | McCamish Pavilion |
| Tue, Jan 20 | vsNC State WolfpackWeek 12Littlejohn Coliseum | L 76–80 | Littlejohn Coliseum |
| Sat, Jan 17 | vsMiami HurricanesWeek 11Littlejohn Coliseum | W 69–59 | Littlejohn Coliseum |
| Tue, Jan 13 | vsBoston College EaglesWeek 11Littlejohn Coliseum | W 74–50 | Littlejohn Coliseum |
| Sat, Jan 10 | @Notre Dame Fighting IrishWeek 10Purcell Pavilion | W 76–61 | Purcell Pavilion |
| Wed, Jan 7 | vsSMU MustangsWeek 10Littlejohn Coliseum | W 74–70 | Littlejohn Coliseum |
| Sat, Jan 3 | @Pittsburgh PanthersWeek 9Petersen Events Center | W 73–68 | Petersen Events Center |
| Wed, Dec 31 | @Syracuse OrangeWeek 9JMA Wireless Dome | W 64–61 | JMA Wireless Dome |
| Sun, Dec 21 | vsCincinnati BearcatsGreenville Winter InvitationalBon Secours Wellness Arena | W 68–65 | Bon Secours Wellness Arena |
| Tue, Dec 16 | vsSouth Carolina GamecocksWeek 7Littlejohn Coliseum | W 68–61 | Littlejohn Coliseum |
| Sat, Dec 13 | vsMercer BearsWeek 6Littlejohn Coliseum | W 70–63 | Littlejohn Coliseum |
| Tue, Dec 9 | vsBYU CougarsJimmy V Classic presented by ModeloMadison Square Garden | L 64–67 | Madison Square Garden |
| Wed, Dec 3 | @Alabama Crimson TideACC/SEC Men's ChallengeColeman Coliseum | L 84–90 | Coleman Coliseum |
| Fri, Nov 28 | vsAlabama A&M BulldogsWeek 4Littlejohn Coliseum | W 92–56 | Littlejohn Coliseum |
| Sun, Nov 23 | vsGeorgia BulldogsShriners Children's Charleston Classic - Palmetto BracketTD Arena | W 97–94 | TD Arena |
| Fri, Nov 21 | vsWest Virginia MountaineersShriners Children's Charleston Classic - Palmetto BracketTD Arena | W 70–67 | TD Arena |
| Mon, Nov 17 | vsNorth Alabama LionsWeek 3Littlejohn Coliseum | W 81–61 | Littlejohn Coliseum |
| Sat, Nov 15 | @Georgetown HoyasWeek 2Capital One Arena | L 74–79 | Capital One Arena |
| Tue, Nov 11 | vsMorehead State EaglesWeek 2Littlejohn Coliseum | W 83–56 | Littlejohn Coliseum |
| Fri, Nov 7 | vsGardner-Webb Runnin' BulldogsWeek 1Littlejohn Coliseum | W 97–59 | Littlejohn Coliseum |
| Mon, Nov 3 | vsNew Hampshire WildcatsWeek 1Littlejohn Coliseum | W 88–38 | Littlejohn Coliseum |